Ecstasy Treatment for Post-Traumatic Stress Shows Promise

Gretchen Ertl for The New York Times

ALTERNATIVE TREATMENT Rick Doblin of the Multidisciplinary Association for Psychedelic Studies, which is financing research into the drug Ecstasy.

Hundreds of Iraq and Afghanistan veterans with post-traumatic stress have recently contacted a husband-and-wife team who work in suburban South Carolina to seek help. Many are desperate, pleading for treatment and willing to travel to get it.

The soldiers have no interest in traditional talking cures or prescription drugs that have given them little relief. They are lining up to try an alternative: MDMA, better known as Ecstasy, a party drug that surfaced in the 1980s and ’90s that can induce pulses of euphoria and a radiating affection. Government regulators criminalized the drug in 1985, placing it on a list of prohibited substances that includes heroin and LSD. But in recent years, regulators have licensed a small number of labs to produce MDMA for research purposes.

“I feel survivor’s guilt, both for coming back from Iraq alive and now for having had a chance to do this therapy,” said Anthony, a 25-year-old living near Charleston, S.C., who asked that his last name not be used because of the stigma of taking the drug. “I’m a different person because of it.”

In a paper posted online Tuesday by the Journal of Psychopharmacology, Michael and Ann Mithoefer, the husband-and-wife team offering the treatment — which combines psychotherapy with a dose of MDMA — write that they found 15 of 21 people who recovered from severe post-traumatic stress in the therapy in the early 2000s reported minor to virtually no symptoms today. Many said they have received other kinds of therapy since then, but not with MDMA.

The Mithoefers — he is a psychiatrist and she is a nurse — collaborated on the study with researchers at the Medical University of South Carolina and the nonprofit Multidisciplinary Association for Psychedelic Studies.

The patients in this group included mostly rape victims, and experts familiar with the work cautioned that it was preliminary, based on small numbers, and its applicability to war trauma entirely unknown. A spokeswoman for the Department of Defense said the military was not involved in any research of MDMA.

But given the scarcity of good treatments for post-traumatic stress, “there is a tremendous need to study novel medications,” including MDMA, said Dr. John H. Krystal, chairman of psychiatry at the Yale School of Medicine.

The study is the first long-term test to suggest that psychiatrists’ tentative interest in hallucinogens and other recreational drugs — which have been taboo since the 1960s — could pay off. And news that the Mithoefers are beginning to test the drug in veterans is out, in the military press and on veterans’ blogs. “We’ve had more than 250 vets call us,” Dr. Mithoefer said. “There’s a long waiting list, we wish we could enroll them all.”

The couple, working with other researchers, will treat no more than 24 veterans with the therapy, following Food and Drug Administration protocols for testing an experimental drug; MDMA is not approved for any medical uses.

A handful of similar experiments using MDMA, LSD or marijuana are now in the works in Switzerland, Israel and Britain, as well as in this country. Both military and civilian researchers are watching closely. So far, the research has been largely supported by nonprofit groups.

“When it comes to the health and well-being of those who serve, we should leave our politics at the door and not be afraid to follow the data,” said Brig. Gen. Loree Sutton, a psychiatrist who recently retired from the Army. “There’s now an evidence base for this MDMA therapy and a plausible story about what may be going on in the brain to account for the effects.”

In interviews, two people who have had the therapy — one, Anthony, currently in the veterans study, and another who received the therapy independently — said that MDMA produced a mental sweet spot that allowed them to feel and talk about their trauma without being overwhelmed by it.

“It changed my perspective on the entire experience of working at ground zero,” said Patrick, a 46-year-old living in San Francisco, who worked long hours in the rubble after the Sept. 11, 2001, attacks searching in vain for survivors, as desperate family members of the victims looked on, pleading for information. “At times I had this beautiful, peaceful feeling down in the pit, that I had a purpose, that I was doing what I needed to be doing. And I began in therapy to identify with that,” rather than the guilt and sadness.

This article has been revised to reflect the following correction:

Correction: November 20, 2012

An earlier version of this article described incorrectly the office arrangement the Mithoefers use to conduct therapy sessions using MDMA. They hold the sessions in an office in a converted house, but they do not conduct the sessions in their home office.

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Stocks sink after Bernake comments; HP takes a hit

A warning from the Federal Reserve chairman about the “fiscal cliff” helped push stocks lower Tuesday.

In a speech to the Economic Club of New York, Chairman Ben Bernanke urged Congress to take action to avoid the steep federal spending cuts and tax increases scheduled to take effect Jan. 1.

Asked in a Q&A session whether the Fed could limit the economic hit posed by the budget-tightening measures, Bernanke said: “If the economy goes off the broad fiscal cliff, I don't think the Fed has the tools to offset that.”

The stock market was already slightly lower. The Dow Jones industrial average sank to a loss of 94 points shortly after Bernanke spoke. By late afternoon, it was down 34 points at 12,760.

Energy companies slumped along with the price of oil, and a surprise announcement from Hewlett-Packard weighed on tech stocks.

HP's executives said that a company HP bought for $10 billion last year lied about its finances. CEO Meg Whitman said that there were “serious accounting improprities, disclosure failures and outright misrepresentations” at the company, Autonomy, which makes search engines. She stopped short of alleging fraud.

HP took an $8.8 billion charge in its latest quarter to bring the accounting value of Autonomy in line with its real value.

In the broader stock market, the Standard & Poor's 500 index lost 5 points to 1,382. The Nasdaq composite index, heavy with technology companies, fell 12 points to 2,904.

Energy stocks and the price of crude oil fell after the president of Egypt predicted that Israel's weeklong offensive in the Gaza Strip would end in hours and the Israeli prime minister said Israel would be a “willing partner” to a cease-fire.

Crude oil was down $2.78, more than 3 percent, to $86.50 per barrel. It traded above $89 earlier in the day. Energy stocks in the S&P declined 0.8 percent as a group.

Housing stocks were among the best. The government said that U.S. builders started construction last month on the most homes and apartments since July 2008.

PulteGroup rose 4.3 percent, Lennar 3.7 percent and D.R. Horton 2.5 percent.

On Monday, the Dow soared 207 points. Investors focused on signs over the weekend that congressional Republicans and the White House might be able to reach a deal to avoid the fiscal cliff.

In the bond market, the yield on the benchmark 10-year U.S. Treasury note edged up to 1.65 percent.

Among stocks making headlines:

— Hormel Foods dropped $1.34, or 4 percent, to $29.96 after its earnings and revenue fell below Wall Street expectations. The company said sales of Spam remained strong, and it increased its annual dividend 13 percent, to 68 cents per share.

— Best Buy fell $1.77, or 13 percent, to $11.98, its lowest in more than a decade. The company, which has struggled for years against increased competition from online electronics retailers, turned in another dismal earnings report.

— Krispy Kreme Doughnuts climbed $1.87, or 25 percent, to $9.41 after it forecast earnings for 2013 above what Wall Street was expecting.

— Green Mountain Coffee rose $1.54, or 6 percent, to $28.87 after picking a new CEO, Brian Kelley of Coca-Cola.

— Groupon gained 31 cents, or 10 percent, to $3.42 after a hedge fund, Tiger Global, said it had bought a 10 percent stake in the company.

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Existing-home sales and builder confidence rise

WASHINGTON -- The housing market recovery showed signs it is continuing to strengthen as sales of existing homes increased 2.1% in October from the previous month and a measure of home-builder confidence jumped in November to its highest level since 2006.

Sales of existing homes rose to a seasonally adjusted annual rate of 4.79 million last month, up from a downwardly revised 4.69 million rate in September, that National Assn. of Realtors reported Monday. Sales were up 10.9% in October from a year earlier.

Stronger demand helped push up the median home price nationwide to $178,600 in October, an increase of 11.1% from a year earlier, the group said. It was the eighth-straight month to show a year-over-year increase, the first time that's happened since 2005-2006.

Fewer houses on the market also helped drive price increases. There were 2.14 million existing homes for sale in October, down 1.4% from September. That translates to a 5.4-month supply at the current sales rate, the lowest level since February 2006.

Sales by distressed homeowners still accounted for a large chunk of activity. Foreclosures and short sales made up 24% of October's sales. That was the same level as in September, but down from 28% a year earlier.

Superstorm Sandy had some negative impact on sales, the group said.

The Northeast, which was hit hard by the storm, was the only region to show a decrease in sales in October from the previous month. Sales were down 1.7% there, while they increased 1.8% in the Midwest, 2.1% in the South and 4.4% in the West.

"Home sales continue to trend up and most October transactions were completed by the time the storm hit, but the growing demand with limited inventory is pressuring home prices in much of the country," said Lawrence Yun, chief economist at the Realtors group. 

He expected more of an impact in the Northeast in coming months.

The improving housing market led to a boost in builder confidence, according to a measure released Monday.

The National Assn. of Home Builders/Wells Fargo Housing Market Index rose five points in November to 46 from the previous month. It was the seventh straight monthly increase, lifting the index to its highest level since May 2006, before the crash of the subprime housing market.

The index remained below 50, indicating that builders who view sales conditions as poor still outnumber those who view them as good. But the index is up sharply from its 19 reading a year ago, the home builders group said.

“Builders are reporting increasing demand for new homes as inventories of foreclosed and distressed properties begin to shrink in markets across the country,” said Barry Rutenberg, a home builder from Gainesville, Fla., and chairman of the builders' group.

“In view of the tightening supply and other improving conditions, many potential buyers who were on the fence are now motivated to move forward with a purchase in order to take advantage of today’s favorable prices and interest rates,” he said. 

ALSO:

FHA's reserves fall into the red

California home sales pop in October

Most aid from mortgage settlement in state going to short sales

Follow Jim Puzzanghera on Twitter and Google+.

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Who Are the ‘Anti-Israel’ Press Behind Rupert Murdoch’s Twitter Attack?

Rupert Murdoch can apologize (as he sort of did) about his “Jewish-owned press” tweet, but he still can’t take it back. And because that tweet is out there, the big question now—after “Why is he still on there?” and “Wow, that’s really offensive, right?”—is which press, exactly, he was referring to. Here’s the tweet that Murdoch sent out on Saturday night: 

Why Is Jewish owned press so consistently anti- Israel in every crisis?

— Rupert Murdoch(@rupertmurdoch) November 18, 2012

After an avalanche of Twitter blowback, Murdoch soon faux-apologized…

“,Jewish owned press” have been sternly criticised, suggesting link to Jewish reporters.Don’t see this, but apologise unreservedly.

— Rupert Murdoch(@rupertmurdoch) November 18, 2012

…”don’t see this” being Murdochian for faux-apology.

RELATED: Rupert Murdoch Brightens Every Newsroom He Enters

As the initial round of shock wears off (The Daily Beast’s Peter Beinart eloquently wrote about how stupid and offensive this tweet was), journalists and editors are now actually trying to make some kind of sense of which outlet or outlets Murdoch may have gotten all drunk-uncle-at-Thanksgiving over. So, with the help of journalists on the case, here’s our best attempt at “Murdoch Whispering“: 

RELATED: How U.K. Tabloids Are Getting Around Prince Harry’s Nudity Warning

He Is Talking About The New York Times Foreign Policy’s Blake Hounshell put it succinctly: 

FWIW Murdoch was probably referring to the NYT with that weird tweet.

— Blake Hounshell (@blakehounshell) November 18, 2012

And it was shared be Buzzfeed’s Ben Smith:

Wolff also assumes, as I did, that Murdoch’s Jewish-owned press meant the Times guardian.co.uk/commentisfree/…

— Ben Smith (@BuzzFeedBen) November 19, 2012

The reason Smith, Hounshell, and The Guardian‘s Michael Wolff all think it’s a Times-centered attack isn’t just because of an anti-Semitic slam against the Sulzbergers (more on this in a tiny bit) but because of Murdoch’s various “wars” and his rivalry with The New York Times. Back in 2010, as Vanity Fair pointed out, Murdoch was warring with executive editor Bill Keller, and he was seen tweeting dissing the well-liked Times‘s public editor, Margaret Sullivan, not too long ago: 

Amusing fuss over NYT public editor.We see all two million daily subscribers as our very public editors.

— Rupert Murdoch(@rupertmurdoch) November 8, 2012

So maybe this tweet was another pot shot, albeit with more anti-Semitic tone. But as Wolff points out, being Jewish-owned doesn’t even apply to The Times anymore, which kinda makes it even more anti-Semitic if he was just going by the Sulzberger surname:

To describe the Times this way is both quizzical, and we can assume, pointed. Because, as it happens, the Times isn’t, per se, “Jewish”. True, the Sulzbergers, who control the company, were once a prominent Jewish family. But the Times’ chairman and publisher, Arthur Sulzberger, is half-Jewish (on his father’s side) and was raised as an Episcopalian. Murdoch knows this full well. So what he is saying is something more like “Jewish-tainted press”, which, all in all, seems more, not less, antisemitic.

He Was Talking About CNN and the AP If you go to the New York Times report on the whole thing that might be referring to The Times, they point to CNN and the AP. “In an earlier message he had said, “CNN and AP bias to point of embarrassment,” writes The Times‘s Amy Chozick.

RELATED: New York Times Devours Gothamist

He Was Channeling Wendi’s Broken English and Trolling His ‘Minders’ “Curiously, Murdoch’s wife Wendi often uses the word ‘Jewish’in an atonal context – ‘You Jewish, right? I know you Jewish!’– that makes Murdoch’s minders jump.  He may even become more retrograde to bedevil his minders.” wrote Wolff. Based on a life experience which includes very blunt Asian relatives and a large extended family, there is a definite possibility that Wendi might not know how harsh  ”You Jewish, right?” comes off. It’s hard to say the same for Rupert.

RELATED: The Vatican Gets Trendy: Puts Newspaper Online, Plans a Paywall

He Wasn’t Talking About Mother Jones‘s Adam Weinstein: 

*I* don’t own any media. You laid me off in 2008. RT @rupertmurdoch: Why Is Jewish owned press so consistently anti-Israel in every crisis?

— Adam Weinstein (@AdamWeinstein) November 18, 2012

Social Media News Headlines – Yahoo! News

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Teenage Boys, Worried About Body Image, Take Health Risks

Béatrice de Géa for The New York Times

David Abusheikh at a gym in Brooklyn. He goes six days a week and says he uses protein supplements to help build muscle.

It is not just girls these days who are consumed by an unattainable body image.

Take David Abusheikh. At age 15, he started lifting weights for two hours a day, six days a week. Now that he is a senior at Fort Hamilton High School in Brooklyn, he has been adding protein bars and shakes to his diet to put on muscle without gaining fat.

“I didn’t used to be into supplements,” said Mr. Abusheikh, 18, who plans on a career in engineering, “but I wanted something that would help me get bigger a little faster.”

Pediatricians are starting to sound alarm bells about boys who take unhealthy measures to try to achieve Charles Atlas bodies that only genetics can truly confer. Whether it is long hours in the gym, allowances blown on expensive supplements or even risky experiments with illegal steroids, the price American boys are willing to pay for the perfect body appears to be on the rise.

In a study to be published on Monday in the journal Pediatrics, more than 40 percent of boys in middle school and high school said they regularly exercised with the goal of increasing muscle mass. Thirty-eight percent said they used protein supplements, and nearly 6 percent said they had experimented with steroids.

Over all, 90 percent of the 1,307 boys in the survey — who lived in the Minneapolis-St. Paul area, but typify what doctors say is a national phenomenon — said they exercised at least occasionally to add muscle.

“There has been a striking change in attitudes toward male body image in the last 30 years,” said Dr. Harrison Pope, a psychiatry professor at Harvard who studies bodybuilding culture and was not involved in the study. The portrayal of men as fat-free and chiseled “is dramatically more prevalent in society than it was a generation ago,” he said.

While college-age men have long been interested in bodybuilding, pediatricians say they have been surprised to find that now even middle school boys are so absorbed with building muscles. And their youth adds an element of risk.

Just as girls who count every calorie in an effort to be thin may do themselves more harm than good, boys who chase an illusory image of manhood may end up stunting their development, doctors say, particularly when they turn to supplements — or, worse, steroids — to supercharge their results.

“The problem with supplements is they’re not regulated like drugs, so it’s very hard to know what’s in them,” said Dr. Shalender Bhasin, a professor of medicine at Boston University School of Medicine. Some contain anabolic steroids, and even high-quality protein supplements might be dangerous in large amounts, or if taken to replace meals, he said. “These things just haven’t been studied very well,” he said.

Anabolic steroids pose a special danger to developing bodies, Dr. Bhasin said. Steroids “stop testosterone production in men,” he said, leading to terrible withdrawal problems when still-growing boys try to stop taking them. Still, the constant association of steroids with elite athletes like Lance Armstrong and Barry Bonds perpetuates the notion that they can be managed successfully.

Online, in bodybuilding forums for teenagers, boys barely out of puberty share weight-lifting regimens and body fat percentages, and judge one another’s progress. On Tumblr and Facebook, teenagers post images of ripped athletes under the heading “fitspo” or “fitspiraton,” which are short for “fitness inspiration.” The tags are spinoffs of “thinspo” and “thinspiration” pictures and videos, which have been banned from many sites for promoting anorexia.

“Lifted b4 school today felt good but was weak as hell,” wrote one boy who said he was 15 and from Tallahassee, Fla., on a message board on Bodybuilding.com in September, saying he bench-pressed 245 pounds. “Barely got it.”

Many of these boys probably see themselves in Mike Sorrentino, “The Situation” from the “Jersey Shore” series on MTV, or the Adam Sackler character, on the HBO series “Girls,” who rarely wears a shirt or takes a break from his crunches.

Mr. Abusheikh, for instance, has a Facebook page full of photos of himself shirtless or showing off his six-pack abs. At his high school, participation in the annual bodybuilding competition hit an all-time high of 30 students this year.

“They ask us about everything,” said Peter Rivera, a physical education teacher at Fort Hamilton High School who helps oversee the competition. “How do I lose weight? How do I gain muscle? How many times a week should I work out?” Some boys want to be stronger for sports, Mr. Rivera said, but others “want to change their body type.”

Compared with a sedentary lifestyle of video games and TV, an obsession with working out may not quite qualify as a health hazard. And instructors like Mr. Rivera say most boys are eager for advice on the healthiest, drug-free ways to get in shape.

With so little known about supplements, it can be difficult, particularly for teenagers, to make wise decisions.

This article has been revised to reflect the following correction:

Correction: November 19, 2012

An earlier version of this article gave an incorrect nationality for the soccer player Cristiano Ronaldo. He is Portuguese, not Brazilian. Because of an editing error, it misstated the number of boys included in the survey. The researchers interviewed 2,793 boys and girls, not 2,800 boys. It also described incorrectly the title of Dr. Shalender Bhasin. He is a professor of medicine at Boston University School of Medicine, not at the Boston Medical Center.

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Federal regulators investigate misleading mortgage ads

WASHINGTON -- Federal regulators said Monday they have opened investigations of 19 financial companies for possible violations of new mortgage advertising rules designed to keep firms from misleading consumers about reverse mortgages and other products.

In addition, the regulators have sent letters to 32 other firms warning them about ads that falsely imply a connection to a government program or provide other potentially misleading information.

The actions, announced Monday, came after a review by the Federal Trade Commission and the Consumer Financial Protection Bureau of about 800 advertisements by mortgage lenders, mortgage brokers and other firms outside the traditional banking system.

“Misrepresentations in mortgage products can deprive consumers of important information while making one of the biggest financial decisions of their lives,” said Richard Cordray, director of the consumer bureau, which shares enforcement of mortgage advertising rules with the FTC. 

"Baiting consumers with false ads to buy into mortgage products would be illegal. We will conduct a fair and rigorous investigation into these issues and will take appropriate action for any violations we find.”

The agencies did not identify the companies under formal investigation or those that received warning letters.

The FTC said it had launched investigations of 13 companies and sent 20 warning letters. The CFPB said it had opened six investigations and issued 12 warning letters. Violations could lead to civil penalties.

In 2011, the FTC enacted the Mortgage Acts and Practices Rule, which prohibits misrepresentations of consumer mortgages through ads or other communications.

The two agencies reviewed ads in newspapers, direct mail, email and online, including on Facebook. 

Some ads featured the image of an eagle or official-looking seal or used abbreviations similar to those for federal programs, implying an affiliation with the government. Others simply promoted lower rates or touted guaranteed approval without being clear about the requirements.

Ads that simply were misleading, such as those containing notes in small type saying that the firm was not a government agency, resulted in warning letters, the agencies said.

"To the extent that something is clearly a misrepresentation and appears to us to be clearly false, that is something that is far more likely to result in opening an investigation," said Kent Markus, assistant director for enforcement at the consumer bureau.

The crash of the housing market has led to fewer mortgage solicitations in recent years, said Thomas B. Pahl, assistant director of the FTC's Division of Financial Practices. But ads could increase as the housing market recovers, and regulators said they wanted to be sure companies knew what was not allowed under the law.

ALSO:

$26 billion in aid given under mortgage settlement, banks say

Most aid from mortgage settlement in state going to short sales

Consumer bureau report raises concerns about reverse mortgages

Follow Jim Puzzanghera on Twitter and Google+.

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A young shooting victim wrestles with his fears

After the nightmares started, Davien Graham avoided his bicycle.

In his dreams, he pedaled his silver BMX bike through his neighborhood, heard gunfire and died.

If I stay off my bike, I'll be safe, he thought.

He placed it in a backyard shed, where it sat for months. But Jan. 12, 2008, dawned so spectacular that Davien decided to risk it.

He ate Cap'n Crunch Berries cereal, grabbed the bike and rode a half-mile west to Calvary Grace, a Southern Baptist church that was his haven.

Davien lived with an unemployed aunt and uncle, a former Crip, and five other kids in a cramped four-bedroom house in Monrovia, about 20 miles east of Los Angeles.

Yet as a 16-year-old junior at Monrovia High School, Davien earned A's and B's, played JV football and volunteered with the video club. He cleaned the church on Saturdays for minimum wage.

If I live right, God will protect me.

That afternoon, sweaty from cleaning, Davien reached for his wallet to buy a snack — only to realize he had forgotten it at home.

After returning to his house, he caught his reflection in the front window. He was 6 feet 2 and wiry. His skinny chest was beginning to broaden. He was trying to add weight to his 160-pound frame in time for varsity football tryouts.

He showered, told his aunt he would be right back and again jumped on his bike, size-14 Nike Jordans churning, heading for a convenience store near the church.

At the store, he bought Arizona fruit punch and lime chili Lay's potato chips. He recognized a kindergarten-age Latino boy and bought him Twinkies.

Davien pedaled down the empty sidewalk along Peck Road. He could hear kids playing basketball nearby. As he neared the church, a car passed, going in the opposite direction. He barely noticed.

He heard car tires crunching on asphalt behind him. He glanced back, expecting a friend.

Instead he heard: "Hey, fool."

The gun was gray. It had a slide. Davien recognized that much from watching the Military Channel.

Behind the barrel, he saw forearms braced to fire and the face of a Latino man, a former classmate.

The gunman shouted, "Dirt Rock!," cursing a local black gang, the Duroc Crips.

Davien's mind raced: Don't panic. Watch the barrel. Duck.

Suddenly, he was falling. Then he was on the ground, looking up at the church steeple and the cross.

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'Twilight' finale dawns with $141.3M weekend

LOS ANGELES (AP) — The sun has set on the "Twilight" franchise with one last blockbuster opening for the supernatural romance.

"The Twilight Saga: Breaking Dawn — Part 2" sucked up $141.3 million domestically over opening weekend and $199.6 million more overseas for a worldwide debut of $340.9 million, according to studio estimates Sunday.

The finale ranks eighth on the list of all-time domestic debuts, and leaves "Twilight" with three of the top-10 openings, joining 2009's "New Moon" (No. 7 with $142.8 million) and last year's "Breaking Dawn — Part 1" (No. 9 with $138.1 million).

Last May's "The Avengers" is No. 1 with $207.4 million. "Batman" is the only other franchise with more than one top-10 opening: July's "The Dark Knight Rises" (No. 3 with $160.9 million) and 2008's "The Dark Knight" (No. 4 with $158.4 million).

Though "Twilight" still is a female-driven franchise, with girls and women making up 79 percent of the opening-weekend audience, the finale drew the series' biggest male crowds. Action-minded guys had more to root for in the finale as Kristen Stewart, Robert Pattinson and Taylor Lautner join in a colossal battle to end the story of warring vampires and werewolves.

"Our male audience particularly has enjoyed this film," said Richie Fay, head of distribution for Lionsgate, whose Summit Entertainment banner releases the "Twilight" movies. "With the action scenes in this one, we're hoping the holdover business will reflect the fact that males have kind of found it out."

The movie also helped lift Lionsgate into the big leagues among Hollywood studios. Paced by its $400 million smash with "The Hunger Games" and now the "Twilight" finale, Lionsgate surpassed $1 billion at the domestic box office for the first time.

Some box-office watchers had expected the last "Twilight" movie to open with a franchise record the way the "Harry Potter" finale did last year with $169.2 million, the second-best domestic debut on the charts.

"I thought that for the final installment, it might eclipse the franchise record, but to look at $141.3 million and say that's a disappointment, that's kind of crazy," said Paul Dergarabedian, an analyst for box-office tracker Hollywood.com. "It's one of the most consistently performing franchises of all time."

The "Twilight" finale took over the No. 1 spot from Sony's James Bond adventure "Skyfall," which slipped to second place with $41.5 million domestically in its second weekend. "Skyfall" raised its domestic total to $161.3 million.

The franchise's third film starring Daniel Craig as Bond, "Skyfall" began rolling out overseas in late October and has hit $507.9 million internationally at the box office. The film's global total climbed to $669.2 million, helping to lift Sony to its best year ever with $4 billion worldwide, topping the studio's $3.6 billion haul in 2009.

"Skyfall" passed the previous franchise high of $599.2 million worldwide for 2006's "Casino Royale."

Steven Spielberg and Daniel Day-Lewis' Civil War drama "Lincoln" expanded nationwide after a week in limited release and came in at No. 3 with $21 million. Distributed by Disney, "Lincoln" lifted its domestic haul to $22.4 million.

The comic drama "Silver Linings Playbook," released by the Weinstein Co., got off to a good start in limited release, taking in $458,430 in 16 theaters for a solid average of $28,652 a cinema. By comparison, the "Twilight" finale averaged $34,717 in 4,070 theaters.

"Silver Linings Playbook" stars Bradley Cooper, Jennifer Lawrence and Robert De Niro in a quirky romance involving a man fresh out of a psychiatric hospital and an emotionally troubled young widow.

Keira Knightley's period drama "Anna Karenina" also started well in limited release with $315,395 in 16 theaters, for an average of $19,712. The Focus Features film stars Knightley in the title role of Leo Tolstoy's tragic romance.

Estimated ticket sales for Friday through Sunday at U.S. and Canadian theaters, according to Hollywood.com. Where available, latest international numbers also are included. Final domestic figures will be released Monday.

1. "The Twilight Saga: Breaking Dawn — Part 2," $141.3 million ($199.6 million international).

2. "Skyfall," $41.5 million ($49.6 million international).

3. "Lincoln," $21 million.

4. "Wreck-It Ralph," $18.3 million ($4.8 million international).

5. "Flight," $8.6 million ($1 million international).

6. "Argo," $4.1 million.

7. "Taken 2," $2.1 million ($2 million international).

8. "Pitch Perfect," $1.3 million ($4.1 million international).

9. "Here Comes the Boom," $1.2 million.

10 (tie). "Cloud Atlas," $900,000.

10 (tie). "Hotel Transylvania," $900,000.

10 (tie). "The Sessions," $900,000.

___

Online:

http://www.hollywood.com

http://www.rentrak.com

___

Universal and Focus are owned by NBC Universal, a unit of Comcast Corp.; Sony, Columbia, Sony Screen Gems and Sony Pictures Classics are units of Sony Corp.; Paramount is owned by Viacom Inc.; Disney, Pixar and Marvel are owned by The Walt Disney Co.; Miramax is owned by Filmyard Holdings LLC; 20th Century Fox and Fox Searchlight are owned by News Corp.; Warner Bros. and New Line are units of Time Warner Inc.; MGM is owned by a group of former creditors including Highland Capital, Anchorage Advisors and Carl Icahn; Lionsgate is owned by Lions Gate Entertainment Corp.; IFC is owned by AMC Networks Inc.; Rogue is owned by Relativity Media LLC.

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Ashlyn Blocker, the Girl Who Feels No Pain

Jeff Riedel for The New York Times

Ashlyn Blocker, who feels no pain, at home in Patterson, GA.

The girl who feels no pain was in the kitchen, stirring ramen noodles, when the spoon slipped from her hand and dropped into the pot of boiling water. It was a school night; the TV was on in the living room, and her mother was folding clothes on the couch. Without thinking, Ashlyn Blocker reached her right hand in to retrieve the spoon, then took her hand out of the water and stood looking at it under the oven light. She walked a few steps to the sink and ran cold water over all her faded white scars, then called to her mother, “I just put my fingers in!” Her mother, Tara Blocker, dropped the clothes and rushed to her daughter’s side. “Oh, my lord!” she said — after 13 years, that same old fear — and then she got some ice and gently pressed it against her daughter’s hand, relieved that the burn wasn’t worse.

Tara Blocker

When Ashlyn was 2, her mother had to wrap her hands to keep her from biting them.

“I showed her how to get another utensil and fish the spoon out,” Tara said with a weary laugh when she recounted the story to me two months later. “Another thing,” she said, “she’s starting to use flat irons for her hair, and those things get superhot.”

Tara was sitting on the couch in a T-shirt printed with the words “Camp Painless But Hopeful.” Ashlyn was curled on the living-room carpet crocheting a purse from one of the skeins of yarn she keeps piled in her room. Her 10-year-old sister, Tristen, was in the leather recliner, asleep on top of their father, John Blocker, who stretched out there after work and was slowly falling asleep, too. The house smelled of the homemade macaroni and cheese they were going to have for dinner. A South Georgia rainstorm drummed the gutters, and lightning illuminated the batting cage and the pool in the backyard.

Without lifting her eyes from the crochet hooks in her hands, Ashlyn spoke up to add one detail to her mother’s story. “I was just thinking, What did I just do?” she said.

Over six days with the Blockers, I watched Ashlyn behave like any 13-year-old girl, brushing her hair, dancing around and jumping on her bed. I also saw her run without regard for her body through the house as her parents pleaded with her to stop. And she played an intense game of air hockey with her sister, slamming the puck on the table as hard and fast as she could. When she made an egg sandwich on the skillet, she pressed her hands onto the bread as Tara had taught her, to make sure it was cool before she put it into her mouth. She can feel warmth and coolness, but not the more extreme temperatures that would cause anyone else to recoil in pain.

Tara and John weren’t completely comfortable leaving Ashlyn alone in the kitchen, but it was something they felt they had to do, a concession to her growing independence. They made a point of telling stories about how responsible she is, but every one came with a companion anecdote that was painful to hear. There was the time she burned the flesh off the palms of her hands when she was 2. John was using a pressure-washer in the driveway and left its motor running; in the moments that they took their eyes off her, Ashlyn walked over and put her hands on the muffler. When she lifted them up the skin was seared away. There was the one about the fire ants that swarmed her in the backyard, biting her over a hundred times while she looked at them and yelled: “Bugs! Bugs!” There was the time she broke her ankle and ran around on it for two days before her parents realized something was wrong. They told these stories as casually as they talked about Tristen’s softball games or their son Dereck’s golf skills, but it was clear they were still struggling after all these years with how to keep Ashlyn safe.

A couple of nights after telling me the story about putting her hand in the boiling water, Ashlyn sat in the kitchen, playing with the headband that held back her long brown hair. We had all been drawing on napkins and playing checkers and listening to Ashlyn and Tristen sing “Call Me Maybe,” when all of a sudden Tara gasped and lifted the hair away from her daughter’s ears. She was bleeding beneath it. The headband had been cutting into her skin entire time we were sitting there.

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A John Lautner-designed home in L.A.

Known for his forward-thinking engineering, architect John Lautner designed the Foster Carling house with a retractable wall of glass separating the outdoor part of the swimming pool from an interior portion in the living room. External steel beams support the hexagonal living space, which is free of internal columns.

Location: 7144 Hockey Trail, Los Angeles 90068

Asking price: $2.995 million

Year built: 1950

House size: Two bedrooms, two bathrooms, 1,999 square feet

Lot size: 16,002 square feet

Features: Redwood planking, raised fireplace, polished concrete floors, built-in furniture, bar, basement, alarm system, carport, skyline views.

About the area: In the third quarter, 86 single-family homes sold in the 90068 ZIP Code at a median price of $930,000, according to DataQuick. That was a 3.8% price increase from the third quarter last year.

Agent: John Galich, Rodeo Realty, (310) 461-0468

—Lauren Beale

To submit a candidate for Home of the Week, send high-resolution color photos on a CD, written permission from the photographer to publish the images and a description of the house to Lauren Beale, Business, Los Angeles Times, 202 W. 1st St., Los Angeles, CA 90012. Send questions to homeoftheweek@latimes.com.

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